张治国(邮箱zhangzg@njucm.edu.cn), 博士,教授,博士研究生导师,江苏省特聘教授。2017年毕业于中国科学院昆明动物研究所获博士学位,2017至2023年在密歇根大学金沙集团1862cc成色从事博士后研究工作,2024年加入金沙集团1862cc成色。
主要从事肝脏疾病和代谢性疾病的发病机理研究,探寻防治脂肪肝、胆汁淤积、肝炎和纤维化等肝病的新型靶标和药物。主持的科研项目包括江苏省特聘教授自然科学类项目、南京中医药大学高层次人才引进科研启动项目。相关研究成果发表在Nature Communications、Cell Mol Gastroenterol Hepatol、Molecular Biology and Evolution、Scientific Reports、Hepatology Communications、Blood等国际著名期刊上,共发表SCI学术论文10余篇 ,授权专利1项,参与编写学术专著一部《树鼩基础生物学与疾病模型》。目前担任Int J Mol Sci, Pharmaceuticals,Cells和Journal of Clinical Medicine等学术杂志审稿专家。
代表性研究论文(*共同第一作者, #通讯作者)
1.Zhiguo Zhang*, Xiao Zhong*, Hong Shen*, Liang Sheng, Suthat Liangpunsakul, Anna S. Lok, M Bishr Omary, Shaomeng Wang, Liangyou Rui (2022). Biliary NIK promotes ductular reaction and liver injury and fibrosis in mice. Nature Communications 13(1): 5111.
2.Linqiang Zhang*, Zhiguo Zhang*, Chengbin Li*, Tingting Zhu, Jing Gao, Hu Zhou, Yingzhuan Zheng, Qing Chang, Mingshan Wang, Jieyu Wu, Liyuan Ran, Yingjie Wu, Huilai Miao, Xiaoju Zou, and Bin Liang (2021). S100A11 Promotes Liver Steatosis via FOXO1-Mediated Autophagy and Lipogenesis. Cellular and Molecular Gastroenterology and Hepatology 11(3): 697-724. (*共同第一作者)
3.Yan-Hu Liu*, Lu Wang*, Zhiguo Zhang*, Newton O Otecko, Saber Khederzadeh, Yongqin Dai, Bin Liang#, Guo-Dong Wang#, Ya-Ping Zhang# (2021). Whole-Genome Sequencing Reveals Lactase Persistence Adaptation in European Dogs. Molecular Biology and Evolution 38(11): 4884-4890. (*共同第一作者)
4.Linqiang Zhang*, Zhiguo Zhang*, Yunhai Li*, Shasha Liao, Xiaoyun Wu, Qing Chang & Bin Liang (2015). Cholesterol induces lipoprotein lipase expression in a tree shrew (Tupaia belangeri chinensis) model of non-alcoholic fatty liver disease. Scientific Reports 5: 15970. (*共同第一作者)
5.Xiao Zhong, Zhiguo Zhang, Hong Shen, Yi Xiong, Yatrik M. Shah, Yong Liu, Xue-Gong Fan, Liangyou Rui (2021). Hepatic NF-kappaB-Inducing Kinase and Inhibitor of NF-kappaB Kinase Subunit alpha Promote Liver Oxidative Stress, Ferroptosis, and Liver Injury. Hepatology Communications 5(10): 1704-1720.